Innovative Treatment Options: Minimally Invasive Targeted Tumor Ablation Technology
Drug/mechanical platform via image localization technology
PTS (para-toluenesulfonamide) is a small-molecule anticancer drug independently developed by Gongwin Biopharm. According to in vitro studies, PTS can penetrate the cancer membrane in a short period of time in contact with cancer cells and accumulate in the cytoplasm in a large amount, and the concentration of cancer cells is several times greater to that in normal cells. When PTS enters cancer cells, it will rupture the intracellular lysosome, release lysozyme and cause necrosis of cancer cells.
PTS also promotes the release of cytochrome c from mitochondria in cancer cells (Cytochrome C), inhibits ATP synthesis, and induces cancer cells to develop apoptosis. This anticancer target and mechanism are very different from other anti-cancer drugs.
Traditional chemotherapy drugs are mainly systemic cell poisoning. Patients often need to bear the side effects of drugs on normal cells, such as bone marrow suppression, hair loss, rash, vomiting, etc. The characteristic of PTS is that it acts directly on the tumor tissue as a direct guide. Because the scope of efficacy is specific and accurate, there is no such side effect that the patient can’t bear.
Due to the above characteristics, we call PTS a “Minimally-Invasive Targeted Tumor Ablation” (MITTA) technology. In addition, according to a series of clinical trials on solid tumors (including head and neck cancer, breast cancer, lung cancer, liver cancer, etc.), PTS has proven its efficacy in killing malignant tumors, and its ability to kill cancer cells does not cause the side effects that traditional chemotherapy drugs have on the human body, coupled with the targeting of PTS by injecting PTS directly into the tumor through image localization technology, which provides relative "safety.”
Please visit the product page for more information about MITTA technology.
References:
1. Para-toluenesulfonamide induces tongue squamous cell carcinoma cell death through disturbing lysosomal stability.
2. The fate of saccharin impurities: the extraction and metabolism of [14C]Toluene-4-sulphonamide and 4-sulphamoyl[14C]benzoic acid in the rat.